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Histone demethylases LSD1 and JMJD2B expression were regulated by triptolide on mRNA level. RPMI8226 cells were treated for 48 h with increasing triptolide (50, 100, 150 nmol/L). Expression of mRNA was then measured by real-time PCR. (A) LSD1 gene expression profile. (B) JMJD2B gene expression profile. Mean±SD of at least three independent experiments (bP<0.05).
