Table 3. Values of BMD and microstructural parameters after genistein treatment. Means±SEM. bP<0.05, cP<0.01 vs control group. eP<0.05, fP<0.01 vs low dose (10 mg/kg) genistein-treatment groups.
Parameters | Control group | Genistein (10 mg/kg) | Genistein (50 mg/kg) |
---|---|---|---|
BMD (mg/mm3) | 761.273±38.076 | 887.893±31.714b | 993.276±47.386ce |
BMC (mg) | 0.097±0.004 | 0.111±0.007b | 0.124±0.008c |
Bone volume (mm3) | 0.079±0.002 | 0.089±0.005c | 0.093±0.004c |
BV/TV (%) | 61.297±1.903 | 67.228±2.578b | 73.568±1.782cf |
Tb.Th (μm) | 61.748±1.444 | 72.794±1.999c | 77.593±7.111c |
BS/BV (%) | 31.993±1.184 | 27.806±1.325c | 25.923±2.112c |
Tb.N (#/mm3) | 10.170±0.296 | 9.182±0.611b | 9.088±0.525b |
Tb.Sp (μm) | 0.102±3.654 | 31.204±1.504c | 28.176±1.850ce |
BMD, bone mineral density; BMC, bone mineral content; BV/TV, trabecular bone volume fraction; BS/BV, bone surface-to-volume ratio; Tb.Th, mean trabecular thickness; Tb.N, trabecular number; Tb.Sp, mean trabecular separation; BV, bone volume.