Table 3. Dynamic parameters for CYP3A1 and CYP3A2 mRNA after DEX administration.
| Parameters | Definitions | Values (% RSE) |
|---|---|---|
| kin,1 (attomol·h−1·μg−1 total RNA) | Transcription rate for CYP3A1 mRNA | 7.47 (4.65) |
| kout,1 (h−1) | Degradation rate for CYP3A1 mRNA | 0.23 (6.45) |
| Smax,1 | Maximum stimulation of the transcription rate of CYP3A1 mRNA | 22.42 (10.90) |
| SC50,1 (μg/mL) | DEX concentration required to reach 50% Smax,1 | 2.39 (15.89) |
| γ1 | Hill-type parameter for CYP3A1 mRNA | 8.01 (6.92) |
| τ1 (h) | Mean transit time of the stimulation of kin,1 | 4.59 (4.71) |
| n1 | Number of the transit compartments for CYP3A1 mRNA | 1 (Fixed) |
| kin,2 (attomol·h−1·μg−1 total RNA) | Transcription rate for CYP3A2 mRNA | 40.00 (19.56) |
| kout,2 (h−1) | Degradation rate for CYP3A2 mRNA | 0.197 (21.00) |
| Smax,2 | Maximum stimulation of the transcription rate of CYP3A2 mRNA | 8.55 (11.72) |
| SC50,2 (μg/mL) | DEX concentration required to reach 50% Smax,2 | 2.82 (38.50) |
| γ2 | Hill-type parameter for CYP3A2 mRNA | 5.00 (13.16) |
| τ2 (h) | Mean transit time of the stimulation of kin,2 | 2.58 (12.79) |
| n2 | Number of the transit compartments for CYP3A2 mRNA | 8 (Fixed) |
RSE, relative standard error.