Table 5. Pharmacodynamic parameters for CYP3A1/2 enzyme activity after DEX administration.
Parameters | Definitions | Values (% RSE) |
---|---|---|
α (pmol·min−1·pmol−1 CYP3A1) | Rate of formation of 6β-OHT for CYP3A1 | 0.463 (22.73) |
β (pmol·min−1·pmol−1 CYP3A2) | Rate of formation of 6β-OHT for CYP3A2 | 7.49 (5.51) |
RSE, relative standard error.