Figure 9.
Interactions between peptide and lipid atoms. (A) Number of atomic contacts between peptide backbone hydrogens and lipid tail hydrogens within 5 Å at low (black) and neutral (red) pH in the simulations. (B) Experimental NOE interaction intensities for the HAFP backbone hydrogen with methylene hydrogen of the DMPC lipid tail.32 (C) Hydrogen bonds between tryptophan indole hydrogens and lipid headgroup carbonyl oxygens. (D) Hydrogen bonds between tryptophan indole hydrogens and lipid headgroup phosphate oxygens. Solid black refers to the simulations at low pH and gray to those at neutral pH.