Table 2. Combination index values of COL+MPSP-001 and Taxol+MPSP-001 in HeLa cells.
| Combination type | Percent of G2/M | COL (nmol/L) |
Taxol (nmol/L) |
MPSP-001 (μmol/L) |
CI | |||
|---|---|---|---|---|---|---|---|---|
| D1 | (Dm)1 | D1 | (Dm)1 | D2 | (Dm)2 | |||
| MPSP-001+COL | 64.10% | 10.00 | 133.32 | NA | NA | 1.00 | 5.45 | 0.27 |
| MPSP-001+Taxol | 41.70% | NA | NA | 25.00 | 105.70 | 1.00 | 1.95 | 0.87 |
The CI is calculated by the following equation: CI=D1/(Dm)1+D2/(Dm)2+D1×D2/[(Dm)1×(Dm)2]. CI>1 indicates antagonism, CI<1 indicates synergy, and CI=1 indicates additivity. COL,colchicines; CI, combination index; NA, Not Applicable.