Table 3. Growth inhibition of MPSP-001 against drug-resistant cell lines.
| Cell lines | Resistant type | VCR |
ADR |
MPSP-001 |
|||
|---|---|---|---|---|---|---|---|
| IC50 (nmol/L) | RF | IC50 (μmol/L) | RF | IC50 (μmol/L) | RF | ||
| KB | Parental | 3.9±0.8 | 110.2 | NT | NT | 8.4±2.9 | 1.2 |
| KB/VCR | MDR↑ | 429.7±18.2 | NT | 10.1±2.1 | |||
| MCF-7 | Parental | NT | NT | 1.7±0.4 | 50.2 | 12.4±2.7 | 1.9 |
| MCF-7/ADR | MDR↑ | NT | 85.3±22.8 | 23.2±7.3 | |||
All resistant cell lines were maintained in drug-free medium for 3 d before seeding for growth inhibition assay. Each value represented the mean±SD. of three independent experiments. The RF was calculated as the ratio of the IC50 value of the multidrug-resistant cells to that of the corresponding sensitive parental cells. VCR, vincristine; ADR, adriamycin; RF, resistant fold; NT, not tested.