Table 1. An overview of the different models of obesity.
| KK-Ay | Ob/ob | Zucker | DIO or Cafeteria diet or DIO DR | UCD-T2M | DIO minipig | |
|---|---|---|---|---|---|---|
| Cause of disease | Monogenic (Ay) and polygenic (KK) | Monogenic | Monogenic | Induced and polygenic | Polygenic | Induced |
| Obesity | Yes | Yes | Yes | Yes | Yes | Yes |
| Hyperphagia | Yes | Yes | Yes | No | Yes | Yes |
| Hyperinsulinemia | Yes | Yes | Yes | Yes | Yes | Yes |
| Glucose intolerance | Yes | Yes | Yes | Yes | Yes | ? |
| Hyperglycemia | Yes | Mild | No | No | Yes | No |
| Weight reducing effect of sibutramine | Marginal | Marginal | No | Yes | ? | ? |
| Weight reducing effect of GLP1 analogues | ? | None or marginal | Yes | Yes | Marginal | Yes |