| Fat deposits |
Nodules (lipomas) in fat ranging in size from rice grains to a fist or larger |
|
| Pain in fat deposits for at least 3 months |
Pain exacerbated by stress, strenuous exercise, trauma, changes in weather, or other; pain can be spontaneous or on palpation; may wax and wane or move around |
|
| Fatigue (asthenia) |
Exacerbated by activities of daily living or exercise |
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| ≥2 accessory symptoms |
|
|
| Cognitive change(s) |
Memory difficulties; difficulty forming thoughts; “brain fog” |
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| Weight gain |
Difficult to lose fatty deposits with lifestyle changes |
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| Vascular involvement |
Visible vascularity near lipomas; telangiectasias; multiple cherry angiomas, multiple petechiae; easy bruising; flushing; hematuria of unknown etiology; heavy or prolonged menstrual bleeding; epistaxis |
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| SAT edema |
Non-pitting |
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| Gastrointestinal complaints |
Gastroesophageal reflux disease, irritable bowel syndrome, bloating, abdominal pain, early satiety |
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| Joint pain and/or stiffness |
Increased in areas of fat deposits |
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| Muscle pain/stiffness |
Especially on awakening or the day after physical activity |
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| Shortness of breath |
In the presence of normal oxygen saturation or as part of the need for oxygen supplementation |
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| Tachycardia |
Varies from palpitations to supraventricular tachycardia requiring beta-blockade |
|
