Table 3. Associations between the Myostatin polymorphisms and haplotypes and BMD in the male-offspring nuclear families (using QTDT).
| rs2293284 | +2278G>A | rs3791783 | Haplotype AGG | Haplotype AAA | Haplotype TGG | |
|---|---|---|---|---|---|---|
| Tests of population stratification | ||||||
| Lumbar spine BMD | 0.0873 | 0.0271 | 0.7146 | 0.2085 | 0.0691 | 0.4929 |
| Femoral neck BMD | 0.9257 | 0.4524 | 0.5155 | 0.7640 | 0.2639 | 0.4894 |
| Total hip BMD | 0.4261 | 0.1967 | 0.9103 | 0.9678 | 0.1292 | 0.4697 |
| Tests of total association | ||||||
| Lumbar spine BMD | 0.6352 | 0.1253 | 0.3089 | 0.2216 | 0.2117 | 0.6743 |
| Femoral neck BMD | 0.7324 | 0.5295 | 0.5475 | 0.3459 | 0.6428 | 0.9498 |
| Total hip BMD | 0.9155 | 0.9887 | 0.2569 | 0.1338 | 0.9090 | 0.5512 |
| Tests of within-family association | ||||||
| Lumbar spine BMD | 0.0879 | 0.2405 | 0.8404 | 0.5675 | 0.0880 | 0.4214 |
| Femoral neck BMD | 0.9245 | 0.7192 | 0.7859 | 0.8882 | 0.4567 | 0.5262 |
| Total hip BMD | 0.4643 | 0.2641 | 0.5012 | 0.4663 | 0.1710 | 0.3547 |
BMD values are adjusted for age, height and weight as covariates. Boldface type indicates significant P values (P<0.05).