Figure 1.

Effects of 18α-GA and 18β-GA on I_Na,P mediated by the WT Nav1.5 channel. (A) and (C) Representative current traces elicited by 500-ms test pulses from -70 mV to 30 mV with 10 mV increments at 0.1 Hz in typical oocytes perfused before and after in 100 μmol/L 18α-GA (A) or 30 μmol/L 18β-GA (C). The membrane potential was held at -120 mV. (B) and (D) Averaged current-voltage relationships of I_Na,P before and after perfusion with 100 μmol/L 18α-GA (B) or 30 μmol/L 18β-GA (D); n=6 per group; ^bP<0.05.