Figure 2.

Effects of 18α-GA and 18β-GA on ΔKPQ Nav1.5 channels. (A) and (C) Original current recordings in the absence and presence of 100 μmol/L 18α-GA (A) or 18β-GA (C). Current was elicited by a depolarizing pulse from a holding potential of -120 mV to -30 mV for 500 ms. Insets show magnified current traces for comparison of the late component. (B) and (D) Averaged current-voltage relationships of I_Na,P before and after perfusion with 100 μmol/L 18α-GA (B) or 18β-GA (D); n=6 per group; ^bP<0.05.