Table 1. Comparative activation and inactivation parameters of WT (at 30 μmol/L) and ΔKPQ (at 100 μmol/L) INa,P in the absence (control) and presence of 18β-GA. Mean±SD. n=6 per group. bP<0.05 vs control.
WT |
ΔKPQ |
|||||||
---|---|---|---|---|---|---|---|---|
Activation | Inactivation | Activation | Inactivation | |||||
V1/2 | K | V1/2 | K | V1/2 | K | V1/2 | K | |
Control | −33.8±1.8 | 6.7±1.6 | −81.8±0.4 | 7.2±0.3 | −36.2±1.8 | 7.0±1.5 | −75.1±0.4 | 4.8±0.4 |
18β-GA | −25.1±1.9b | 7.7±1.7 | −88.1±0.3b | 6.9±0.2b | −28.6±1.6b | 7.8±1.3b | −80.5±0.5b | 5.1±0.4 |
Washout | −31.6±1.7 | 7.6±1.5 | −83.0±0.4 | 7.2±0.4 | −33.2±1.8 | 7.0±1.5 | −75.4±0.4 | 4.7±0.4 |