Table 2. Results of the hypothesis validation for the full regression model.

Parameter	Covariate	ΔOFV	P-value
CL/F	Age	−6.714	P>0.005
	Weight	−128.412	P<0.005
	CO	−0.431	P>0.005
	Dose	−3.242	P>0.005
	Gender	−1.105	P>0.005
V/F	Age	−0.154	P>0.005
	Weight	−0.528	P>0.005
	CO	−3.644	P>0.005
	Dose	−2.145	P>0.005
	Gender	−2.233	P>0.005
Ka	Age	−2.550	P>0.005
	Weight	−1.476	P>0.005
	CO	−1.560	P>0.005
	Dose	−2.279	P>0.005
	Gender	−2.410	P>0.005