Table 4. Population parameter values for the final model.
| Parameter | Estimate | RSE (%) | 95% CI | Shrinkage |
|---|---|---|---|---|
| CL/F (L/h) | 1.04 | 1.4 | 1.011–1.069 | |
| V/F (L) | 12.1 | 5.6 | 10.767–13.433 | |
| Ka (h−1) | 1.56 | 14.3 | 1.230–1.997 | |
| Weight (kg) | 0.567 | 6.7 | 0.489–0.637 | |
| ωCL/F | 0.195 | 7.0 | 0.106–0.141 | 20% |
| ωV/F | 0.163 | 45.5 | 0.127–0.175 | 44.9% |
| ɛ | 0.028 | 18.6 | 0.018–0.035 | 31% |
RSE (%), percentage of relative standard error (100%×SE/EST); ωCL/F, ωV/F, variance of the CL/F, V/F, parameters, respectively; ɛ, variance of intra-individual deviation of fitted concentration. The ωKa was fixed at 0, as there were not enough points in the absorption phase.