Table 1. Effect of β-asarone on cell viability and MMP in OGD/R treated PC12 cells.
Groups | n | Cell viability (OD value) |
---|---|---|
Normal control | 10 | 0.79±0.04 |
Model control | 10 | 0.46±0.02c |
Nimodipine (10 μmol/L) | 10 | 0.74±0.04f |
β-asarone (20 μg/mL) | 10 | 0.64±0.07c,f |
β-asarone (30 μg/mL) | 10 | 0.75±0.09f |
β-asarone (45 μg/mL) | 10 | 0.56±0.08c,f |
Normal control cells were grown in full culture medium under normoxic conditions. Model control cells were treated with OGD/R (2 h OGD+24 h R). Therapeutic cells were incubated with nimodipine (10 μmol/L) or beta-asarone (20, 30, or 45 μg/mL) respectively for 3 h (1 h before OGD and 2 h OGD). They were incubated with full and drug-free culture medium for 24 h. β-asarone (20, 30, or 45 μg/mL) and nimodipine (10 μmol/L) both significantly increased cell viability and MMP in OGD/R treated cells. Mean±SD for 10 samples.
cP<0.01 vs normal control.
fP<0.01 vs OGD/R treated group.