Table 2.
Estimated regression coefficients (95% confidence intervals) on the association between plasma inflammatory proteins at baseline and at 5-year follow-up in the IRAS
| Outcome: follow-up ln(MCRI) | Beta-coefficients (95% CI) | p-value |
|---|---|---|
| Ln(CRP) n=783 | ||
| Adjusted for baseline ln(MCRI) | −0.035 (−0.059, −0.011) | 0.004 |
| + age, sex, ethnicity | −0.046 (−0.071, −0.021) | <0.001 |
| + BMI, waist circumference | −0.016 (−0.041, 0.0083) | 0.193 |
| + smoking, alcohol consumption, energy expenditure, family history of diabetes | −0.015 (−0.040, 0.0098) | 0.234 |
| + HDL, TG, ALT | −0.017 (−0.042, 0.0076) | 0.174 |
| + FBG, SI, AIR | −0.013 (−0.038, 0.012) | 0.311 |
| Ln(PAI-1) n=779 | ||
| Adjusted for baseline ln(MCRI) | −0.060 (−0.092, −0.028) | <0.001 |
| + age, sex, ethnicity | −0.096 (−0.13, −0.062) | <0.001 |
| + BMI, waist circumference | −0.060 (−0.094, −0.026) | 0.001 |
| + smoking, alcohol consumption, energy expenditure, family history of diabetes | −0.057 (−0.092, −0.022) | 0.001 |
| + HDL, TG, ALT | −0.047 (−0.083, −0.012) | 0.009 |
| + FBG, SI, AIR | −0.045 (−0.081, −0.091) | 0.014 |
| Fibrinogen n=780 | ||
| Adjusted for baseline ln(MCRI) | −0.00040 (−0.00088, 0.000075) | 0.099 |
| + age, sex, ethnicity | −0.00046 (−0.00095, 0.000028) | 0.065 |
| + BMI, waist circumference | 0.000040 (−0.00044, 0.00052) | 0.870 |
| + smoking, alcohol consumption, energy expenditure, family history of diabetes | 0.000077 (−0.00041, 0.00057) | 0.758 |
| + HDL, TG, ALT | 0.000066 (−0.00042, 0.00055) | 0.791 |
| + FBG, SI, AIR | 0.000043 (−0.0044, 0.00053) | 0.861 |
| Ln(leptin) n=750 | ||
| Adjusted for baseline ln(MCRI) | −0.035 (−0.066, −0.0044) | 0.026 |
| + age, sex, ethnicity | −0.15 (−0.19, −0.099) | <0.001 |
| + BMI, waist circumference | −0.044 (−0.10, 0.011) | 0.115 |
| + smoking, alcohol consumption, energy expenditure, family history of diabetes | −0.041 (−0.097, 0.014) | 0.146 |
| + HDL, TG, ALT | −0.059 (−0.11, −0.0037) | 0.037 |
| + FBG, SI, AIR | −0.042 (−0.098, 0.014) | 0.140 |
| Ln(TNF-α) n=779 | ||
| Adjusted for baseline ln(MCRI) | −0.071 (−0.14, −0.00087) | 0.047 |
| + age, sex, ethnicity | −0.12 (−0.20, −0.048) | 0.001 |
| + BMI, waist circumference | −0.085 (−0.16, −0.014) | 0.020 |
| + smoking, alcohol consumption, energy expenditure, family history of diabetes | −0.076 (−0.15, −0.0039) | 0.039 |
| + HDL, TG, ALT | −0.056 (−0.13, 0.016) | 0.126 |
| + FBG, SI, AIR | −0.056 (−0.13, 0.017) | 0.129 |