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. Author manuscript; available in PMC: 2014 May 5.
Published in final edited form as: Sci Transl Med. 2012 Apr 11;4(129):129ra44. doi: 10.1126/scitranslmed.3003249

Fig 1.

Fig 1

Progressive abstraction of cerebrovascular physiology. (A) Relevant cerebrovascular anatomy: brain tissue (BT), cerebrospinal fluid (CSF), and cerebral arterial network (AN). (B) Schematic representation of the main cerebrovascular compartments and associated physiological variables: cerebral blood flow (CBF), arterial blood pressure (ABP), and intracranial pressure (ICP); the collapsed venous segment is also shown. (C) Lumped circuit-model representation of cerebrovascular physiology: cerebral blood flow q(t), cerebral arteriovenous flow q1(t), and arterial blood pressure pa(t). ICP denotes both extra-luminal pressure and the effective downstream pressure for cerebral perfusion.