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. Author manuscript; available in PMC: 2015 May 1.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2014 Mar 6;34(5):966–975. doi: 10.1161/ATVBAHA.113.302484

Figure 4. Deficiency of HDL impairs thymocyte apoptosis in sepsis.

Figure 4

A) Lack of HDL in apoAI−/− mice assessed by FPLC; B and C) Impaired thymocyte apoptosis in apoAI−/− mice in sepsis. ApoAI−/− and control C57BL/6J mice were subjected to CLP (21G needle, half ligation) for 18 h, thymocyte apoptosis was analyzed with TUNEL assay (B) and CD4/CD8 profiles were analyzed (C). n= 11 per group; D) Impaired GC-induced thymocyte apoptosis in apoAI−/− mice. ApoAI−/− and control C57BL/6J mice were administered Dex (8mg/kg body weight, i.p.) for18 h, and thymocyte apoptosis was analyzed with TUNEL assay. n = 5 – 8 per group. *p < 0.05.