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. Author manuscript; available in PMC: 2015 May 1.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2014 Mar 6;34(5):966–975. doi: 10.1161/ATVBAHA.113.302484

Figure 7. Lecithin cholesteryl acyltransferase (LCAT) over expression restores SR-BI−/− HDL’s regulatory activity on modulating GC-induced thymocyte apoptosis.

Figure 7

Thymocytes from wild type mice were cultured in complete medium and incubated with/without 10μM corticosterone for 18 h in the presence /absence of HDL (SR-BI+/+ HDL, 0.272±0.013 mg/mL by protein; SR-BI+/+ LCAT-tg HDL, 0.332±0.008 mg/mL by protein; SR-BI−/− HDL, 0.193±0.006 mg/mL by protein; SR-BI−/− LCAT-tg HDL, 0.373±0.003 mg/mL by protein;). The protein concentration of LCAT-tg HDL was adjusted to the same level of non-LCAT-tg HDL. The cell death was analyzed by 7-AAD staining (A and B) and Trypan Blue assays (C). n = 4 with duplicate measurements.