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. 2014 May 5;9(5):e95151. doi: 10.1371/journal.pone.0095151

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© 2014 Castellanos et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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A: Snapshot from the UCSC genome browser showing the TR site in intron 13 of the Otog gene and 77 kb downstream from the TSS of MyoD. B: EMSA of GST-TBX1 and the TR motif in the Otog-MyoD locus with or without unlabeled TR double stranded oligonucleotide competitor. C: Luciferase reporter assays using the intronic element showed a 2.5 fold increase (Student's t-test, *p<0.05; means ±SD; n≥3) in activation when in the presence of TBX1. D: Expression of MyoD is lost in the 1^st pharyngeal arch core mesoderm in Tbx1 ^-/- embryos at E10.5 (arrow) but it remains in the somites. Forebrain expression in both embryos represents a staining artifact.