Table 2. Pharmacokinetic parameters of single instillation of NSAID eye drops in aqueous humor.
Cmax (ng/mL)* | Tmax (hr) | T1/2 (hr) | kel (hr−1) | AUC0–8 (ng·hr/mL)† | MRT (hr) | |
Diclofenac | 300±110 | 1 | 1.94 | 0.358 | 972±44 | 2.30 |
Bromfenac | 57.8±36.1 | 2 | 2.34 | 0.296 | 224±33 | 3.06 |
Amfenac | 25.9±7.4 | 1 | 2.39 | 0.290 | 131±11 | 3.03 |
AUC0–8: The area under the aqueous humor drug concentration-time curve from 0 to 8 hours, kel: elimination rate constant, MRT: mean residence time, *: Mean ± S.D., †: Mean ± SEM.