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. 2014 May 5;9(5):e96481. doi: 10.1371/journal.pone.0096481

Table 2. Pharmacokinetic parameters of single instillation of NSAID eye drops in aqueous humor.

Cmax (ng/mL)* Tmax (hr) T1/2 (hr) kel (hr−1) AUC0–8 (ng·hr/mL) MRT (hr)
Diclofenac 300±110 1 1.94 0.358 972±44 2.30
Bromfenac 57.8±36.1 2 2.34 0.296 224±33 3.06
Amfenac 25.9±7.4 1 2.39 0.290 131±11 3.03

AUC0–8: The area under the aqueous humor drug concentration-time curve from 0 to 8 hours, kel: elimination rate constant, MRT: mean residence time, *: Mean ± S.D., †: Mean ± SEM.