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. 2014 May 5;9(5):e96610. doi: 10.1371/journal.pone.0096610

Figure 5. Representative photographs of immunohistochemical features of these proteins in different lesions.

Figure 5

(A) Expression of c-Jun, cystatin A, involucrin and SPRR3 were detected in the precursor lesions, including normal epithelium, low-grade intraepithelial neoplasia (LGIN) and high-grade intraepithelial neoplasia (HGIN) using immunohistochemistry. From the normal epithelium to LGIN and HGIN, expression of these genes decreased markedly and sometimes even totally disappeared in LGIN and HGIN. (B) Statistical analysis was performed to determine the expression of these proteins during the progress of esophageal tumorigenesis using SPSS17.0 software.