. 2014 May 5;9(5):e96610. doi: 10.1371/journal.pone.0096610

Table 4. Immunohistochemistry abnormalities in different lesions of ESCC.

		Precursor lesions		P-value
Protein	Normal	LGIN	HGIN	P^a	P^b	P^c
	Mean ± SD	Mean ± SD	Mean ± SD
c-Jun	494.3±88.4	344.4±77.5	369.6±114.7	0.000	0.005	0.598
cystatin A	349.7±41.9	193.9±46.3	71.48±45.9	0.000	0.000	0.000
involucrin	409.6±38.7	254.9±82.7	142.9±25.9	0.000	0.000	0.025
SPRR3	413.3±43.5	234.8±108.8	120.6±76.7	0.000	0.000	0.078

Note: Mean: Average of the integral intensity of all samples; a, Esophageal normal epithelium vs LGIN; b, Esophageal normal epithelium vs HGIN; c: LGIN vs HGIN.