Table 1. Quantitative levels of anti-PGL-Tb1 and anti-ESAT-6/CFP10 antibodies (median) as measured by optical density in different groups of active TB patients according to their HIV status, disease localization and in individuals without active TB according to their risk of TB infection.
| Active TB | HIV-infected | HIV-uninfected | HIV-unknown | ||||||||
| N | Median OD (IQR) | N | Median OD (IQR) | N | Median OD (IQR) | ||||||
| PGL-Tb1 | ESAT-6/CFP10 | PGL-Tb1 | ESAT-6/CFP10 | PGL-Tb1 | ESAT-6/CFP10 | ||||||
| Pulmonary (P) | 68 | 0.189 | 0.126 | 270 | 0.107 | 0.071 | 293 | 0.123 | 0.071 | ||
| (0.126–0.388) | (0.070–0.202) | (0.069–0.188) | (0.051–0.116) | (0.078–0.226) | (0.045–0.108) | ||||||
| Extrapulmonary (EP) | 34 | 0.170 | 0.140 | 46 | 0.083 | 0.062 | 67 | 0.103 | 0.064 | ||
| (0.102–0.315) | 0.077–0.221) | (0.062–0.152) | (0.047–0.097) | (0.073–0.163) | (0.053–0.090) | ||||||
| p P versus EP | 0.1895 | 0.6367 | 0.0549 | 0.1804 | 0.0886 | 0.4387 | |||||
| All patients | 102 | 0.185* | 0.130* | 316 | 0.103* | 0.069* | 360 | 0.117** | 0.070** | ||
| (0.124–0.347) | (0.074–0.208) | (0.067–0.172) | (0.049–0.108) | (0.076–0.214) | (0.046–0.105) | ||||||
| No active TB | |||||||||||
| N | Median OD (IQR) | N | Median OD (IQR) | ||||||||
| Low risk of LTBI | PGL-Tb1 | ESAT-6/CFP10 | High risk of LTBI | PGL-Tb1 | ESAT-6/CFP10 | ||||||
| Blood donors | 459 | 0.056 | 0.045 | Hospitalized patients | 73 | 0.077 | 0.060 | ||||
| (0.039–0.082) | (0.034–0.063) | (0.055–0.146) | (0.034–0.103) | ||||||||
| Healthy Community Adults | 100 | 0.067 | 0.059 | Health Care Workers | 121 | 0.072 | 0.052 | ||||
| (0.046–0.100) | (0.043–0.080) | (0.052–0.106) | (0.039–0.081) | ||||||||
| Healthy Family Contacts | 104 | 0.089 | 0.053 | ||||||||
| - | - | (0.059–0.160) | (0.042–0.076) | ||||||||
| - | - | Cured TB patients | 88 | 0.112**** | 0.076**** | ||||||
| (0.080–0.203) | (0.052–0.120) | ||||||||||
| Total | 559 | 0.057 | 0.047 | Total | 386 | 0.086*** | 0.057*** | ||||
| (0.040–0.085) | (0.035–0.067) | (0.057–0.149) | (0.041–0.087) | ||||||||
Footnotes: TB: tuberculosis; HIV: human immunodeficiency virus; LTBI: latent tuberculosis infection; N; number of serum tested; OD: optical density; * HIV-infected versus HIV-uninfected, versus HIV-unknown: p<0.0001; ** HIV-uninfected versus HIV-unknown: p>0.05; *** Low risk versus high risk individuals: p <0.0001;****Cured TB patients versus other HR of LTBI: p<0.01; IQR (interquartile range).