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. 2014 May 5;9(5):e96367. doi: 10.1371/journal.pone.0096367

Table 8. Specificity of the serology test based on the ELISA using the PGL-Tb1 or the ESAT-6/CFP10 antigens and their cumulative results in the different groups of individuals classified as low risk of TB infection.

Antigen n/N Blood donors n/N Healthy subjects p value of blood donors versus Healthy subjects n/N Total
Percentage (95% CI)
PGL-Tb1* 418/459 91.1 (88.0–93.4) 90/100 90.0 (82.4–94.5) p = 0.7038 508/559 90.9 (88.2–93.1)
ESAT-6/CFP10** 421/459 91.7 (88.8–94.0) 90/100 90.0 (82.4–94.5) p = 0.5573 511/559 91.4 (88.7–93.5)
PGL-Tb1 versus ESAT-/CFP10 (p value) p = 0.8141 p = 1.000 p = 0.8334
Both antigens 389/459 84.8 (81.1–87.9) 80/100 80.0 (70.9–86.8) p = 0.2336 469/559 83.9 (80.6–86.9)

Footnotes: n/N = number of negative tests/number of tested sera in each group; * Cut-off value for PGL-Tb1: OD = 0.130; ** Cut-off value for ESAT-6/CFP10: OD = 0.100.