Table 10. Sensitivity of the serology test based on the ELISA using the PGL-Tb1 and ESAT-6/CFP10 antigens and their cumulative results in active TB patients stratified by Smear Microscopy (SM), TB localization and HIV status.

Antigen	HIV status	Pulmonary				p value SM(−) versus SM(+)	Extrapulmonary				p valueSM(−) versus SM(+)
		n/N	SM-negative	n/N	SM-positive		n/N	SM-negative	n/N	SM-positive
			% (95% CI)		% (95% CI)			% (95% CI)		% (95% CI)
PGLTb1*	Infected	31/40	77.5 (61.6–89.2)	19/28	67.9 (47.7–84.1)	0.4130	22/30	73.3 (54.1–87.7)	2/4	50.0 (9.6–93.2)	0.5636
	Uninfected	19/64	29.7 (18.9–42.4)	85/206	41.3 (34.5–48.3)	0.1072	11/37	29.0 (15.4–45.9)	2/9	22.2 (2.8–60.0)	1.0000
	Unknown	49/113	43.4 (34.1–53.0)	87/180	48.3 (40.855.9)	0.4704	19/55	34.6 (22.2–48.6)	3/12	25.0 (5.5–57.2)	0.7371
	Uninfected +unknown	68/177	38.4 (31.2–46.0)	172/386	44.6 (39.5–49.7)	0.1989	30/92	32.3 (22.9–42.8)	5/21	23.8 (8.2–47.2)	0.6022
	Total	99/217	45.6 (38.9–52.5)	191/414	46.1 (41.3–51.1)	0.9331	52/122	42.3 (33.4–51.5)	7/25	28.0 (12.1–49.4)	0.2626
ESAT6/CFP10**	Infected	28/40	70.0 (53.5–83.4)	14/28	50.9 (30.7–69.4)	0.1294	20/30	66.7 (47.2–82.7)	3/4	75.0 (19.4–99.4)	1.0000
	Uninfected	21/64	32.8 (21.6–45.7)	62/206	30.1 (23.9–36.9)	0.7567	9/37	24.3 (11.8–41.2)	2/9	22.2 (2.8–60.0)	1.0000
	Unknown	30/113	26.6 (18.7–35.7)	59/180	32.8 (26.0–40.2)	0.2972	9/55	16.4 (7.7–28.8)	2/12	16.7 (2.1–48.4)	1.0000
	Uninfected +unknown	51/177	28.8 (22.3–36.1)	121/386	31.4 (26.8–36.2)	0.5563	18/92	19.6 (12.0–29.2)	4/21	19.1 (5.5–41.9)	1.0000
	Total	79/217	36.4 (30.0–43.2)	135/414	32.6 (28.1–37.4)	0.3761	38/122	31.2 (23.1–40.2)	7/25	28.0 (12.1–49.4)	0.8166
Both antigens	Infected	33/40	82.5 (67.2–92.7)	19/28	67.9 (47.7–84.4)	0.2451	23/30	73.3 (54.1–87.7)	3/4	75.0 (19.4–99.4)	1.0000
	Uninfected	28/64	43.8 (31.4–56.7)	104/102	50.5 (43.5–57.5)	0.3914	16/37	43.2 (27.1–60.5)	4/9	44.4 (13.7–78.8)	1.0000
	Unknown	56/113	49.6 (40.0–59.1)	111/180	61.7 (54.1–68.8)	0.0523	22/55	40.0 (27.0–54.1)	3/12	25.0 (5.5–57.2)	0.5120
	Uninfected +unknown	84/177	47.5 (39.9–55.1)	215/386	55.7 (50.6–61.7)	0.0699	38/92	46.3 (35.3–57.7)	7/21	33.3 (14.6–57.0)	0.3313
	Total	117/217	53.9 (47.0–60.7)	234/414	56.6 (51.6–61.4)	0.5554	61/122	50.0 (40.8–59.2)	10/25	40.0 (23.1–61.3	0.3884

Footnotes: TB: tuberculosis; HIV: human immunodeficiency virus; n/N = number of positive tests/number of tested sera in each group; SM: smear microscopy; * Cut-off value for PGL-Tb1: OD = 0.130; ** Cut-off value for ESAT-6/CFP10: OD = 0.100; CI: confidence interval.