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. 2014 May 5;9(5):e96836. doi: 10.1371/journal.pone.0096836

Figure 2. MVs facilitate the growth of inoculated tumors.

Figure 2

(A) Nude mice inoculated with 786-0 cells. 786-0 cells mixed with MVs or RNase-MVs in M199 or M199 (control) were inoculated subcutaneously in the nude mice sacrificed at 36d following inoculation; (B) Tumor incidence. There was a higher tumor incidence in nude mice treated with MVs as compared to RNase-MVs or control; (C) Tumor volume. In contrast to RNase-MVs or control, MVs led to the development of a bigger tumor in nude mice. *P<0.05, MVs vs. RNase-MVs or control; (D) Ki-67 and TUNEL staining. In the presence of MVs, there were more Ki-67-positive staining cells and fewer cells staining positive for TUNEL on tumor sections.