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. 2014 May 5;9(5):e96836. doi: 10.1371/journal.pone.0096836

Figure 4. MVs induce the activation of AKT and ERK1/2 signaling in tumor tissues.

Figure 4

(A)(B) Gel photograph and densito-metric analysis of of AKT, p-AKT, ERK1/2 and p-EREK1/2 protein expression in inoculated tumors. MVs led to a significant phosphorylation of tumor AKT and ERK1/2 proteins. The density of each band was determined. Values in the graph are expressed as densitometry ratios of p-AKT/β-actin, p-ERK1/2/β-actin, p-AKT/AKT or p-ERK1/2/ERK1/2 as folds over control (dotted line). *P<0.05, MVs vs. control; # P<0.05, RNase-MVs vs. MVs.