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. 2014 May 5;9(5):e96691. doi: 10.1371/journal.pone.0096691

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© 2014 Yu et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) The representative I _Ca tracings obtained by a pulse protocol shown in the inset before apamin (a), after apamin (b) and after nifedipine (c) at time points indicated by arrows a through c, respectively, in (B). (B) The time course of peak I _Ca measured at 0 mV. (C) The summary of drug effects normalized to baseline. (D) The representative tracings of I _Na obtained by a pulse protocol shown in the inset before apamin (a), after apamin (b) at time points indicated by arrows a and b, respectively, in (E). (E) The time course of peak I _Na at –40 mV. (F) The summary of current densities before and after apamin.