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. 2014 May 5;9(5):e96510. doi: 10.1371/journal.pone.0096510

Figure 1. Morphologic changes in the placentas of normal and preeclamptic patients.

Figure 1

A. Hematoxylin–eosin (HE) staining. CTB: cytotrophoblast, which forms the inner layer of the trophoblast; STB: syncytrophoblast, which forms the surface of the villi; End: endothelial cell, a flat cell in the villi. Localization of 15-LO-1/2 (B) and HIF-1α (C). Increased expression of 15-LO-1/2 and HIF-1α gave rise to thicker syncytiotrophoblast membranes, more syncytial knots, and thicker vessels in preeclamptic placentas than in normal placentas (n = 10).