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. 2014 May 5;9(5):e96427. doi: 10.1371/journal.pone.0096427

Figure 3. PKC, ERK/MAPK, CAMKII and intracellular calcium release negatively regulate Rv3416 mediated VGCC expression.

Figure 3

PMA stimulated THP1 cells were incubated with inhibitors to indicated molecules (see Experimental Procedures) for 1h prior to stimulation with Rv3416. L-type VGCC levels were monitored by FACS 72h post stimulation. Bold lines represent cells stimulated with 30 µg/ml of Rv3416, while dotted lines represent cells incubated with inhibitors to indicated molecules followed by stimulations with Rv3416. Thin lines represent unstimulated cells. One of four independent experiments is shown.