Table 1. Published PET tracers for visualizing transplanted islets.
Method for labeling | Tracer | References | Radioactivity | Islet donor species | Comments |
Labeling of islets directly | [18F]FDG | 17 , 33 | 4–6 h | human, rat | Available for clinical use already Short radioactivity High uncharacteristic washout |
[18F]FHBG | 18 - 20 | 1–3 mo | human, rat, mouse | Longer radioactivity Use of viral vector |
|
Labeling of islets via intravenous infusion | [11C]DTBZ | 23 | Approximately 30 min | rat | Specific labeling of islets via VMAT2 Short radioactivity |
[64Cu]/[18F]-labeled exendin-4 | 26 , 36 | Over 4 h | human | Specific labeling of islets via GLP-1 receptor | |
[18F]- labeled fallypride | 30 | Over 1.5 h | rat | Specific labeling of islets via D2/D3 receptor Available for clinical use already Binds to other organs (mainly the brain) |
|
[68Ga]-labeled biotin | 32 | Over 30 min | human | Specific labeling of islets via avidin-biotin interaction Prevention of IBMIR |