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. Author manuscript; available in PMC: 2015 Jan 1.
Published in final edited form as: Xenotransplantation. 2013 Nov 5;21(1):72–83. doi: 10.1111/xen.12073

Figure 1. Human platelet aggregation induced by wild-type (WT) pAEC, human AEC (hAEC) and genetically modified pAEC.

Figure 1

hAEC- and pAEC-induced human platelet aggregation were measured by aggregometry (Chrono-log). Representative curves of human platelet aggregation induced by hAEC and pAEC. After human whole blood was incubated with WT pAEC, removed, diluted, and recalcified, aggregation of human platelets occurred. Incubation of blood with hAEC resulted in minimal aggregation. Platelet aggregation was reduced when whole blood was incubated with GTKO/CD46/TBM pAEC. Addition of hirudin (1U/mL) to GTKO/CD46/TBM pAEC almost completely prevented platelet aggregation in whole blood.