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. Author manuscript; available in PMC: 2015 Jan 1.
Published in final edited form as: Xenotransplantation. 2013 Nov 5;21(1):72–83. doi: 10.1111/xen.12073

Figure 4. The effect of various genetic modifications on pAEC-induced human platelet aggregation.

Figure 4

(A) When human platelet aggregation associated with WT pAEC (54%) was compared with that to hAEC (4%), a significant difference was observed (p<0.001). WT/CD46 (38%), WT/TFPI (38%), and GTKO (44%), and pAEC significantly reduced the aggregation associated with WT pAEC (all p<0.05).

(B) GTKO/CD46/CD55 (39%), GTKO/CD46/TBM (27%), and GTKO/CD46/EPCR (33%) pAEC induced significantly less aggregation than GTKO pAEC (44%) (all p<0.05). (*p<0.05, **p<0.01, ***p<0.001), but did not reduce aggregation to that associated with hAEC.