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. Author manuscript; available in PMC: 2015 Jan 1.
Published in final edited form as: Xenotransplantation. 2013 Nov 5;21(1):72–83. doi: 10.1111/xen.12073

Figure 6. Anti-thrombin inhibit human platelet aggregation induced by GTKO/CD46 and GTKO/CD46/TBM pAEC.

Figure 6

Hirudin at 5IU/ml completely inhibited GTKO/CD46 pAEC-induced platelet aggregation in human blood (4%) while it had a partial effect at 1IU/ml (18%) when compared with control (41%; *p<0.05, **p<0.01). Platelet aggregation induced by GTKO/CD46/TBM pAEC was almost completely prevented by hirudin (1 or 5IU/ml; 5% and 4% aggregation, respectively) (**p<0.01), which was comparable to that induced by hAEC (4%).