FIG. 3.

ABR threshold shifts (TS) averaged across 2–16 kHz as a function of time course. TS showed a similar maximal increase at 8 h after noise exposure in both treatment and control groups. As shown in the control groups, the TS gradually decreased over a 7-day period and then stabilized. Compared to controls, animals treated with NAC/HPN-07 showed a similar temporary TS at 8 h post-noise but a significant improvement in the recovery of TS from 24 h to 21 days. Data was combined for animals remaining in each group at the time of testing. The number of ears was: 18 (8 h), 18 (24 h), 16 (7 days), 20 (21 days). Data were analyzed using a two-way ANOVA with the Bonferroni test, **p < 0.01, ***p < 0.0001 and plotted as mean ± SEM.