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. 2014 Apr 7;6(1):e2014026. doi: 10.4084/MJHID.2014.026

Table 2.

Treatments recommended for Latent Tuberculosis Infection

DRUG REGIMEN LENGTH OF TREATMENT ADULT DOSE SIDE EFFECTS COMMENTS
INH 6–9 months 300mg/day Hepatotoxicity
Neurotoxicity
RIF 4–6 months 600 mg/day Hepatotoxicity
Thrombopenia
Interaction with other drugs
INH+RIF 3 months Idem as above Not recommended in HIV
INH+RPT 3 months 900mg+900mg per week DOT
PZA+RIF No longer used because of toxicity

INH: isoniazid; RIF: rifampicin; RPT: rifapentine; PZA: pyrazinamide; DOT: Directly Observed Therapy.