Table 2.
DRUG REGIMEN | LENGTH OF TREATMENT | ADULT DOSE | SIDE EFFECTS COMMENTS |
---|---|---|---|
INH | 6–9 months | 300mg/day | Hepatotoxicity Neurotoxicity |
RIF | 4–6 months | 600 mg/day | Hepatotoxicity Thrombopenia Interaction with other drugs |
INH+RIF | 3 months | Idem as above | Not recommended in HIV |
INH+RPT | 3 months | 900mg+900mg per week | DOT |
PZA+RIF | No longer used because of toxicity |
INH: isoniazid; RIF: rifampicin; RPT: rifapentine; PZA: pyrazinamide; DOT: Directly Observed Therapy.