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. 2014 Mar 14;306(9):L816–L828. doi: 10.1152/ajplung.00323.2013

Fig. 2.

Fig. 2.

CS increased FOXO3 oxidation and lipid peroxidation products in the lungs. Representative mass spectra of oxidized residues of FOXO3 in mouse lungs exposed to air (no residue oxidation identified) and CS (Asp198 oxidation; see underlined residue “D”) (A). CS exposure increased the levels of 4-hydroxy-2-nonenal (4-HNE) and malondialdehyde (MDA) in lungs of WT littermates, which were further increased in SIRT1+/− mice. SIRT1 genetic overexpression significantly attenuated the levels of MDA plus 4-HNE in response to CS exposure (B). Data are shown as means ± SE (n = 3 to 4 per group). *P < 0.05, **P < 0.01, ***P < 0.001 vs. the corresponding air-exposed groups; +P < 0.05, +++P < 0.001 vs. the corresponding CS-exposed WT littermates.