Fig. 3.

Lack of effect of SIRT1 on levels of glutathione (GSH), GSH disulfide (GSSG), and GSH/GSSG ratio in mouse lungs exposed to CS. SIRT1^+/−, SIRT1 Tg, and their WT littermates were exposed to CS for 3 days. Neither CS exposure nor loss and gain of SIRT1 function altered the total GSH, its oxidized/disulfide form (i.e., GSSG), or GSH/GSSG ratio in mouse lungs (A and B). SRT1720 treatment did not have any effect on the levels of GSH, GSSG, or GSH/GSSG ratio in SIRT1^+/− mice or WT mice (C). Data are shown as means ± SE (n = 3 to 4 per group). +P < 0.05 vs. WT mice.