Fig. 4.

Effect sizes before and after Free Water Elimination. Maps of Cohen's d for differences in the values of fractional anisotropy (FA), mean (MD), axial (AD) and radial diffusivity (RD) in patients with mild cognitive impairment compared to controls throughout the mean FA skeleton for the uncorrected dataset (uncor) and after correcting for partial volume effect (cor). Effect sizes are displayed according to their values—small (thin white line, blue in online version), medium (thick white line, red in online version) and large (thick dark grey line, yellow in online version). Statistical maps are overlaid on the registration target brain transformed into MNI152 space. Images are displayed in radiological view.