Table S1.

Comparison of individual tracts between MCI and controls, before and after correction with Free Water Elimination, with a two-way mixed-design ANOVA. Tract-specific average values (SD) of fractional anisotropy (FA, no unit) and mean diffusivity (MD, 10^− 3 mm² s^− 1) are provided. Abbreviations: UNC, uncinate fasciculus; PHC, parahippocampal cingulum; MCI, mild cognitive impairment; HC, healthy control; FWE, Free Water Elimination; F is the F-test statistic and p the associated probability.

			Uncorrected	FWE-corrected	Within-subjects contrast (FWE)		Within-subjects contrast (FWExGroup)		Between-subjects effect (Group)
			Mean (SD)	Mean (SD)	F	p	F	p	F	p
Fornix	FA	MCI	0.201 (0.027)	0.237 (0.045)
		HC	0.224 (0.023)	0.272 (0.037)	183.788	< .001***	4.243	.046*	8.546	.006**
	MD	MCI	1.876 (0.238)	1.020 (0.125)
		HC	1.660 (0.205)	1.065 (0.069)	315.976	< .001***	10.249	.003**	6.816	.012*
UNC left	FA	MCI	0.401 (0.025)	0.429 (0.053)
		HC	0.377 (0.030)	0.418 (0.029)	38.262	< .001***	1.371	.248	3.239	.079
	MD	MCI	0.880 (0.048)	0.802 (0.040)
		HC	0.861 (0.043)	0.781 (0.027)	415.116	< .001***	.069	.793	2.983	.091
UNC right	FA	MCI	0.395 (0.027)	0.427 (0.056)
		HC	0.380 (0.023)	0.420 (0.025)	35.287	< .001***	.441	.510	1.319	.257
	MD	MCI	0.892 (0.036)	0.816 (0.047)
		HC	0.872 (0.035)	0.790 (0.023)	220.592	< .001***	.450	.506	5.580	.023*
PHC left	FA	MCI	0.342 (0.033)	0.386 (0.032)
		HC	0.311 (0.023)	0.356 (0.023)	1331.118	< .001***	.029	.865	12.050	.001**
	MD	MCI	0.845 (0.054)	0.786 (0.040)
		HC	0.846 (0.042)	0.785 (0.028)	453.435	< .001***	.029	.866	.001	.970
PHC right	FA	MCI	0.364 (0.037)	0.409 (0.033)
		HC	0.331 (0.026)	0.379 (0.026)	611.395	< .001***	.380	.541	11.522	.002**
	MD	MCI	0.827 (0.067)	0.767 (0.042)
		HC	0.829 (0.048)	0.772 (0.031)	202.064	< .001***	.095	.759	.054	.818

Significance: *p < .05, **p < .01, ***p < .001.