Table 1.
Physiologic responses to infusions of KCl and NaCl
Uninfused | KCl Infused | NaCl Infused | |
---|---|---|---|
Infusion volume, ml/3 h | 0 | 12 ± 0 | 2.92 ± 0.36 |
Infused K, mmol | 0 | 1363 ± 54 | 0 |
Infused Na+, mmol | 0 | 452 ± 56 | 452 ± 56 |
Urinary volume, ml/3 h | 0.96 ± 0.17 | 4.9 ± 0.64 * | 1.1 ± 0.3 |
Hematocrit, % | |||
Initial | 45.3 ± 1.4 | 45.8 ± 0.5 | 44.6 ± 0.7 |
After 3 h | 45.0 ± 1.5 | 38.6 ± 1.0† | 41.8 ± 0.7† |
Values are means ± SE. KCl infusion group was infused with 150 mM KCl at a variable rate to elevate and maintain the plasma K+ concentration to 5.5 mM and 0.9% saline was concurrently infused to maintain an overall volume infusion rate of 4 ml/h over 3 h. NaCl infusion group received the same amount of NaCl that was infused into the KCl rats in a paired fashion. Uninfused group was prepared in the same manner but not infused. Infused K+ and Na+ and volumes were calculated from the infusion rate, recorded every 15 min, and the concentrations infused.
P < 0.05 in KCl infused vs. NaCl infused.
P < 0.05 before vs. after infusion.