Table 1.
Top 50 genes downregulated in 3D + HGF but not in 2D + HGF
| Gene Symbol | Affymetrix Probeset ID | Fold Change in 2D + HGF | Fold Change in 3D + HGF | MAPK 3D | |
|---|---|---|---|---|---|
| 1 | IL8 | Cfa.3510.1.S2_at | −1.01077 | −235.476 | Yes |
| 2 | CCL7 | Cfa.16337.1.S1_s_at | 1.0226 | −65.0118 | Yes |
| 3 | CXCL10 | Cfa.16590.1.S2_at | −1.03483 | −59.1649 | No |
| 4 | CCL2 | Cfa.3851.1.S1_s_at | −1.41702 | −53.8085 | Yes |
| 5 | KLHL24 | Cfa.1578.1.S1_at | −1.24551 | −48.1247 | Yes |
| 6 | Cfa.382.1.S1_at | −1.62398 | −43.6817 | Yes | |
| 7 | ACTA2 | CfaAffx.24064.1.S1_at | 1.00428 | −43.5689 | Yes |
| 8 | Cfa.12151.1.A1_at | −1.66839 | −36.735 | Yes | |
| 9 | IDO1 | CfaAffx.9573.1.S1_at | −1.06122 | −34.3352 | Yes |
| 10 | FILIP1L | Cfa.12291.1.A1_at | −1.11281 | −33.5399 | Yes |
| 11 | DAO | CfaAffx.17496.1.S1_s_at | −1.15505 | −31.333 | Yes |
| 12 | Cfa.14008.1.A1_at | −1.45647 | −25.9029 | Yes | |
| 13 | AGPHD1 | Cfa.2465.1.A1_at | −1.92466 | −24.6451 | Yes |
| 14 | TAGLN | CfaAffx.20384.1.S1_at | 1.07404 | −21.6368 | Yes |
| 15 | TMEM234 | CfaAffx.16726.1.S1_at | −1.90083 | −19.818 | Yes |
| 16 | LRRC19 | CfaAffx.3462.1.S1_at | −1.72585 | −19.0976 | Yes |
| 17 | HBP1 | CfaAffx.6846.1.S1_at | −1.66142 | −18.8617 | Yes |
| 18 | PARP9 | CfaAffx.18544.1.S1_s_at | −1.67553 | −18.6741 | Yes |
| 19 | STAP2 | CfaAffx.29150.1.S1_at | 1.08093 | −17.7161 | Yes |
| 20 | TTC30A/TTC30B | CfaAffx.20940.1.S1_at | −1.94454 | −17.5377 | Yes |
| 21 | GBP1 | Cfa.18819.1.S1_at | −1.13765 | −16.6679 | Yes |
| 22 | ENOSF1 | Cfa.18734.1.S1_at | −1.09466 | −15.7093 | Yes |
| 23 | HLA-DMA | Cfa.18297.1.S1_at | −1.55155 | −14.9005 | Yes |
| 24 | HLA-DMA | CfaAffx.2197.1.S1_s_at | −1.67813 | −14.2987 | Yes |
| 25 | LAMB2 | Cfa.20623.1.S1_at | 1.18279 | −13.8203 | Yes |
| 26 | TMEM37 | CfaAffx.8275.1.S1_at | −1.91704 | −13.5176 | Yes |
| 27 | VLDLR | Cfa.9396.1.A1_s_at | −1.51316 | −13.5103 | Yes |
| 28 | ACTA1 | Cfa.307.3.S1_at | −1.00364 | −13.3361 | Yes |
| 29 | PCMTD2 | Cfa.21242.1.S1_at | −1.483 | −12.974 | Yes |
| 30 | CCNG2 | CfaAffx.13729.1.S1_at | 1.09686 | −12.3896 | Yes |
| 31 | ANKRD1 | Cfa.16041.1.S1_at | 1.70275 | −12.3206 | No |
| 32 | Cfa.14049.1.A1_at | −1.69276 | −11.8271 | Yes | |
| 33 | IDO1 | CfaAffx.9573.1.S1_s_at | 1.04883 | −11.8065 | Yes |
| 34 | CCNG2 | CfaAffx.13734.1.S1_s_at | 1.14545 | −11.7528 | Yes |
| 35 | DAO | Cfa.15688.1.A1_at | −1.06773 | −11.752 | Yes |
| 36 | HBP1 | Cfa.16872.1.S1_s_at | −1.82799 | −11.7115 | Yes |
| 37 | Cfa.4114.1.S1_at | −1.87317 | −11.2273 | Yes | |
| 38 | ACTA1/ACTA2 | CfaAffx.18955.1.S1_s_at | −1.05663 | −11.212 | Yes |
| 39 | DTX3L | CfaAffx.18558.1.S1_at | −1.87712 | −11.2001 | Yes |
| 40 | KLHL24 | CfaAffx.18456.1.S1_s_at | −1.50436 | −11.1903 | Yes |
| 41 | LOC100856683 | CfaAffx.22409.1.S1_at | −1.06832 | −10.9963 | Yes |
| 42 | Cfa.9097.1.A1_at | 1.53325 | −10.9001 | Yes | |
| 43 | Cfa.2835.1.A1_at | −1.79756 | −10.869 | Yes | |
| 44 | Cfa.9524.1.A1_at | −1.00196 | −10.3906 | No | |
| 45 | FYCO1 | Cfa.10325.1.A1_at | −1.79487 | −10.3473 | Yes |
| 46 | EDN1 | Cfa.125.1.S1_s_at | −1.38134 | −10.1535 | Yes |
| 47 | TAGLN | Cfa.12238.1.A1_a_at | 1.05448 | −9.65693 | Yes |
| 48 | SRPX | Cfa.12650.1.S1_at | −1.00325 | −9.6031 | Yes |
| 49 | TAGLN | CfaAffx.20384.1.S1_s_at | 1.05297 | −9.55568 | Yes |
| 50 | PDCD4 | CfaAffx.16895.1.S1_s_at | −1.81865 | −9.54413 | Yes |
3D, three-dimensional; HGF, hepatocyte growth factor; 2D, two-dimensional.