Table 2.
Cortisol Levels Before and After Treatment of Each Patient, for Each Treatment Arm (Octreotide and Placebo)
| Treatment Arm | Patient | Pretreatment Period |
Posttreatment Period |
Posttreatment Means Expressed as Percentage of Pretreatment Means | Change From Pretreatment Mean to Posttreatment Mean, % | ||
|---|---|---|---|---|---|---|---|
| Cortisol Mean | AUC | Cortisol Mean | AUC | ||||
| Octreotide | 1 | 15.0 | 176.5 | 2.1 | 22.7 | 14.1 | −85.9 |
| 2 | 8.8 | 105.1 | 8.4 | 87.2 | 95.0 | −5.0 | |
| 3 | 33.5 | 401.4 | 28.3 | 239.4 | 84.6 | −15.4 | |
| 4 | 4.2 | 50.2 | 4.3 | 45.0 | 102.3 | 2.3 | |
| 5 | 4.4 | 50.6 | 5.0 | 50.5 | 114.0 | 14.0 | |
| 6 | 26.2 | 315.9 | 25.4 | 280.7 | 96.9 | −3.1 | |
| 7 | 5.3 | 64.8 | 5.0 | 55.6 | 94.3 | −5.7 | |
| 8 | 9.2 | 78.6 | 8.8 | 95.7 | 94.7 | −5.3 | |
| 9 | 30.4 | 365.5 | 31.1 | 201.6 | 102.0 | 2.0 | |
| 10 | 8.2 | 90.5 | 8.2 | 90.7 | 99.8 | −0.2 | |
| Total | 14.5 (11.3) | 169.9 (138.1) | 12.6 (11.0) | 116.9 (90.2) | 89.8 (27.6) | −10.2 (27.6) | |
| Placebo | 1 | 49.1 | 593.7 | 19.3 | 206.1 | 39.4 | −60.6 |
| 2 | 12.0 | 145.3 | 11.1 | 116.2 | 92.0 | −8.0 | |
| 3 | 29.1 | 350.9 | 25.0 | 263.0 | 85.9 | −14.1 | |
| 4 | 4.3 | 52.1 | 6.1 | 64.6 | 140.6 | 40.6 | |
| 5 | 3.0 | 36.7 | 5.5 | 57.4 | 181.1 | 81.1 | |
| 6 | 25.1 | 300.7 | 22.1 | 241.4 | 88.1 | −11.9 | |
| 7 | 4.8 | 57.6 | 4.9 | 55.1 | 102.9 | 2.9 | |
| 8 | 6.7 | 79.2 | 10.5 | 115.9 | 157.1 | 57.1 | |
| 9 | 28.2 | 337.4 | 28.4 | 313.5 | 100.6 | 0.6 | |
| 10 | 8.7 | 104.2 | 8.2 | 89.0 | 93.7 | −6.3 | |
| Total | 17.1 (15.2) | 205.8 (183.2) | 14.1 (8.8) | 152.2 (95.4) | 108.1 (40.8) | 8.1 (40.8) | |
P = .2541 comparing percentage of change from before treatment to after treatment. P = .4260 comparing octreotide with placebo cortisol AUC, pretreatment period. P = .1824 comparing octreotide with placebo cortisol AUC, posttreatment period. P < .0001 comparing before treatment with after treatment using repeated measures, octreotide (same adjusted for sex). P < .0001 comparing before treatment with after treatment using repeated measures, placebo (same adjusted for sex).