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. 2014 Feb 10;99(5):E848–E854. doi: 10.1210/jc.2013-4109

Figure 2.

Figure 2.

A, TNFα release from MNCs after exposure to varying physiological concentrations of T and DHEA. Compared with MNC exposure to baseline concentrations of DHEA (175 ng/dL) or T (50 ng/dL), the absolute change (Δ) in TNFα release increased after exposure to T concentrations of 125 ng/dL (P < .007) and 250 ng/dL (P < .002), and a DHEA concentration of 1750 ng/dL (P < .0001). B, TNFα release from MNCs after exposure to varying physiological concentrations of T preceded by preincubation with the AR antagonist flutamide. Compared with a maximum T-stimulated baseline (100%) after MNC exposure to T concentrations of 50, 125, and 250 ng/dL, there was a significant (P < .0009) ≥60% reduction in TNFα release in response to flutamide preincubation, to a level that was similar to vehicle alone or flutamide within vehicle.