Table 3.
Androgen Levels in Women With PCOS Before and 3 Months After Treatment With Metformin 1500 mg/d and Before and After hCG Stimulation
| Pre Metformin |
Post Metformin |
hCG P Value | Metformin P Value | |||
|---|---|---|---|---|---|---|
| Pre hCG | Post hCG | Pre hCG | Post hCG | |||
| T, ng/dL | 59.7 ± 6.2 | 74.9 ± 10.0 | 45.8 ± 6.9 | 69.9 ± 10.8 | <.05 | <.05 |
| Androstenedione, ng/dL | 171.4 ± 12.4 | 259.3 ± 22.6 | 161.5 ± 14.2 | 241.5 ± 26.1 | <.001 | .4 |
| 17OH progesterone, ng/dL | 57.9 ± 4.3 | 214.8 ± 38.8 | 56.8 ± 5.8 | 196.1 ± 35.9 | <.001 | .8 |
| SHBG, nmol/L | 36.5 ± 3.8 | 40.7 ± 4.3 | 33.9 ± 4.0 | 38.7 ± 4.4 | .4 | .7 |
Data are expressed as mean ± SE. Subjects who were studied in the luteal phase were removed from the analysis (final n = 25). To change to SI units, multiply T by 0.0347 (for nmol/L), androstenedione by 0.0349 (for nmol/L), and 17OH progesterone by 0.0303 (for nmol/L).