FIGURE 2.

(A) Baseline diffusion connectometry analysis for patient 1, demonstrated the affected areas as being inferior occipito-frontal fasciculus (Inf. Occ. Fr.), cingulum (Cing.), and posterior part of the corpus callosum (CC). (B, posterior view) and (C, lateral view) a year later, extensive changes are now evident bilaterally in the corpus callosum; cinguli and posterior limb of the internal capsule (Int. Cap.) and in parts of inferior occipito-frontal fasciculi. (D) Cortical end-points of the affected fiber tracts at the time of the second scan demonstrate involvement of fibers originating from precentral gyrus (Precent. gyr.) and frontal areas with relative sparing of postcentral gyrus (Postcent. gyr.).