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. 2014 Apr 29;8:270. doi: 10.3389/fnhum.2014.00270

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Copyright © 2014 Abhinav, Yeh, El-Dokla, Ferrando, Chang, Lacomis, Friedlander and Fernandez-Miranda.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Baseline diffusion connectometry analysis for patient 2, demonstrated the affected areas as being parts of the corpus callosum (CC), corticospinal (Cort-sp.) tracts, and inferior occipito-frontal (Inf. Occ. Fr.) fasciculi bilaterally. (B, left lateral view) and (C, posterior view) 6 months later shows extensive bilateral changes now involving corticospinal tracts, frontal fibers coursing toward the brainstem in the posterior limb of the internal capsule (Int. Cap.); cinguli (Cing.); superior longitudinal (Sup. Long.); and inferior occipito-frontal fasciculi. (D) Cortical end points for the second scan display predominant involvement of fibers originating from the precentral gyrus (Precent. gyr.) and frontal areas.