Figure 1.

Experimental constraints on glomerular location and activation. (A) (top) The experimental setup to study glomerular activation in the dorsal surface of the olfactory bulb; (bottom) sagittal view of an olfactory bulb and its laminar organization; GL, glomerular layer; EPL, external plexiform layer; GCL, granule cell layer; (B) Location of the 127 activated glomeruli in the dorsal olfactory bulb included in this study; (C) Intrinsic optical signal imaging of evoked activity during presentation of two natural odors, coffee and kiwi; (D) Schematic organization of the olfactory bulb used for all simulations; GL, glomerular layer; MCL, mitral cell body layer; EPL, external plexiform layer; GCL, granule cell layer; the olfactory bulb volume was rendered in the {x, y, z} space as an ellipsoid defined by [(x − 50)/1050]² + [(y − 12.75)/1200]² + (z/1050)² = 1, truncated along the main axis at 2150 μm; (E) Glomerular activation patterns, normalized for intensity, by several natural odors; the 3D location for the 127 glomeruli (colored spheres) was mapped from their 2D position in (B); snapshots illustrate activation during presentation of the different odors (raw data kindly provided by A. Carleton). (A) (top), (B,C) are reprinted by permission from Macmillan Publishers: Vincis et al. (2012); (A) (bottom) is adapted from Elsaesser and Paysan (2007).